| abstract |
(57) [Summary] [Structure] A diazabicycloalkene derivative represented by the following general formula (1) or a salt thereof, and a therapeutic agent for hypertension, a therapeutic agent for angina, and a therapeutic agent for asthma containing the same. [Chemical 1] [In the formula, R 1 means a group represented by the following formula (2) or (3)] The compound (1) of the present invention has an excellent potassium channel opening action, and is a disease caused by contraction of smooth muscle, for example, ischemic heart disease such as angina, asthma, frequent urination, It is effective for the aftereffects of subarachnoid hemorrhage and peripheral arterial occlusion. In addition, it has a slow onset of action, has a strong and persistent antihypertensive effect, has an excellent effect of increasing renal blood flow, and is highly safe, and thus is particularly useful as a therapeutic agent for hypertension. . |