| abstract |
(57) [Summary] [Objective] Oxyalkyne, a drug containing the same, and a method for producing the compound and the drug [Structure] As a racemic or diastereomeric mixture or in an optically active form, the compound of the general formula I [In the formula, a substituent Y at the meta- or para-position: (In the formula, R 1 is CH 3 or NH 2 , and R 2 is H or C. H 3 and R 3 are H, C 1-3 -alkyl or COCH 3 , and Ar is a group An aromatic residue selected from the following, wherein the substituents R 4 , R 5 and R 6 are the same or different, and are H, F, Cl, Br and C, respectively. 1-6 -alkyl, CF 3 or C 1-6 -alkoxy, R 7 is H, F, Cl, Br, C 1-3 -alkyl or CF 3 . ) Is shown. ] A new oxyalkyne, which inhibits 5-lipoxygenase or 5- and 12-lipoxygenase and is used as a drug. |