| abstract |
(57) [Summary] (Modified) [Purpose] Retains cell-adhesive protein-like activity, Disclosed is a peptide derivative containing a peptide sequence having an enhanced cancer metastasis-inhibiting ability as compared with Arg-Gly-Asp as an essential constituent unit, which has high stability in blood and can be synthesized by a simple means. [Structure] A peptide derivative represented by the formula (I) or a pharmacologically acceptable salt thereof, and a cancer metastasis inhibitor containing the same as an active ingredient. [R represents a peptide sequence represented by the following formula (II). -[Z] -Arg-X-Asp- [Y] (II) (Arg represents L- or D-arginine, Asp represents L- or D- aspartic acid, and X represents L- or D-leucine or Represents D-isoleucine []. Represents that the residue in [] may or may not be present, and when present, Z represents L- or D-aspartic acid, and Y represents L-serine or L-threoni. )] |