| abstract |
(57) Abstract: A transdominant mutant of the HIV virus TAT protein or a functional fragment of the protein containing at least one mutation, wherein the mutation is 38 Amino acid residues different from natural residues are present at positions 40, 41, 45 or 47, position 41 is different from alanine or threonine, and position 47 is different from alanine or histidine A mutant, a method for producing the mutant, and a pharmaceutical composition comprising the harmful mutant as an active ingredient for treating or preventing HIV infection. [Effect] It became possible to treat or prevent HIV infection. |