| abstract |
(57) [Summary] (Modified) [Structure] A silyl ether compound represented by the general formula (I), particularly the general formula (V), is added to an organic solvent in the presence of a quaternary ammonium salt in the presence of NH 4 F. -A method for removing a silyl group of a silyl ether compound, which comprises reacting with ammonium acid fluoride represented by HF to produce a corresponding hydroxyl group-containing compound. (Wherein R represents an aliphatic hydrocarbon group, an alicyclic hydrocarbon group or an aromatic hydrocarbon group; R 1 , R 2 and R 3 represent a lower alkyl group, a phenyl group or an aralkyl group, and R 8 Is hydrogen, lower alkyl group, aralkyl group, etc., R 9 is hydrogen atom, carboxylic acid protecting group, alkali metal atom, etc., Y represents a methylene group, a sulfur atom or the like. [Effect] According to the above method, it is possible to efficiently remove the silyl group of the silyl ether compound which is unstable under strongly acidic or basic conditions using a relatively inexpensive raw material. |