| abstract |
(57) [Summary] (Modified) [Structure] Soluble KL that contains the extracellular receptor binding region of the natural kit ligand (KL) and does not have the cytoplasmic and transmembrane regions of the natural kit ligand. Also, a method for producing soluble KL using a DNA sequence encoding the soluble KL, an expression vector expressing the soluble KL, transformants and recombinant DNA technology. In addition, for the treatment of hematopoietic disorders and to improve hematopoietic recovery after radiation and chemotherapy in cancer patients, whether autologous or allogeneic, with or without bone marrow transplants. Use as a powerful drug for treatment. [Effect] With this soluble KL, such as aplastic anemia, convulsive nocturnal erythroglobinuria (PNH), polycythemia, chronic osteoporotic leukemia, skeletal metaplasia, thrombocythemia, and acute leukemia. Stem cell diseases can also treat many diseases such as AIDS, malaria, vitamin B 12 and folate deficiency. |