| abstract |
(57) [Summary] (Modified) [Objective] The present invention provides a sulfonamide heterocyclic thrombin inhibitor useful for inhibiting thrombus formation. [Structure] The thrombin inhibitor of the present invention is represented by the following formula: It also includes all stereoisomers and salts thereof. (In the formula, G is the formula (G1) or the formula (G2); n is 0, 1 or 2; R is hydrogen, hydroxyalkyl, aminoalkyl, alkyl, cycloalkyl, arylalkyl, alkenyl, alkynyl, amidoalkyl, aryl. Alkoxyalkyl or amino acid side chains; R 1 and R 2 are independently hydrogen, lower alkyl, cycloalkyl, aryl, hydroxy, alkoxy, keto, thioketal, thioalkyl, thioaryl, amino or alkylamino, or R 1 and R 2. Together with the carbon to which they are attached form a cycloalkyl, aryl or heteroaryl ring; R 3 is alkyl, aryl, arylalkyl, Heteroaryl, quinolinyl or tetrahydroquinolinyl) |