| abstract |
(57) [Summary] (Modified) [Purpose] Treatment of vomiting and motion sickness [Constitution] 6-heterocyclic group-4-amino-1,3,4,5-tetrahydrobenz of general formula ( 1 ) [ cd] indole or a pharmaceutically acceptable salt thereof as an active ingredient, a pharmaceutical preparation for the treatment of emesis and motion sickness. Some of the compounds used in the method of this invention are new. [Wherein R 1 is hydrogen, methyl, ethyl, cyclopropylmethyl, benzyl, formylacetyl, etc .; R 2 is hydrogen, Methyl, cyclopropylmethyl, etc .; R 3 is hydrogen, methyl, amino-closing group; Het is tetrazolyl group; 5- or 6-membered aromatic heterocyclic group; |