| abstract |
(57) [Summary] (Modified) [Purpose] To provide a method for treating vomiting and motion sickness and a pharmaceutical preparation suitable therefor. A pharmaceutical preparation for the treatment of vomiting or motion sickness containing a compound represented by the general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient, and a compound of the general formula (1) which is the active ingredient, and A pharmaceutically acceptable salt thereof. [In the formula, R 1 is hydrogen, C 1-4 alkyl, cyclopropylmethyl, aryl-C 1-4 alkyl, -CO-R 4 (R 4 = H, C 1-4 (halo) alkyl, C 1-4 alkoxy, phenyl) and the like; R 2 is H, C 1-4 alkyl and the like; R 3 is H, C 1-4 alkyl, amino closed Group; He t is a 5- or 6-membered heterocyclic group such as a (substituted) tetrazolyl group] |