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filingDate 1993-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1994-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H06211646-A
titleOfInvention Composition containing nanoparticles and method for producing the same
abstract (57) [Summary] [Object] To provide a therapeutic or diagnostic composition having a controlled cloud point and a method for producing the same. The composition comprises nanoparticles in which a nonionic surfactant is adsorbed on the surface as a surface modifier, and charged phospholipids are contained in combination as a cloud point modifier. The cloud point modifier is present in the composition in an amount sufficient to raise the cloud point of the surface modifier. Preferred nonionic surfactant surface modifiers are poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoylphosphatidylglycerol. Further disclosed is a method for producing the nanoparticles, comprising the step of contacting the nanoparticles with a cloud point modifier for a time and under conditions sufficient to raise the cloud point of the surface modifier.
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