| abstract |
(57) [Summary] (Corrected) [Constitution] The enzyme P450 C24 derived from the rat kidney P450 C24 producing E. coli strain is expressed by the following formula. (In the formula, R 4 represents H or OH, and R 5 is R 4 is H. Represents OH, and when R 4 is OH, R 5 is H or O Represents H. In the presence of ferredoxin and NADPH-ferredoxin reductase, the compound represented by the formula (Wherein, R 1 is OH, R 2 is .R 3 representing a = O H or R 1 and R 2 total, represents H when R 1 is OH, R 2 represents H, R 1 and When R 2 represents ═O, R 3 represents H or OH, R 4 represents OH when R 1 represents H, and OH represents when R 2 represents H, and ═O represents R 1 and R 2 as a whole. vitamin D 3 derivative production method of represented by represents.) H or OH when. [Effect] The obtained compound is effective for treating bone lesions such as osteoporosis. |