| abstract |
(57) [Summary] [Objective] To provide a novel erythromycin derivative, a method for producing them and their use as a medicine. ## STR1 ## This erythromycin derivative has the following formula (I): [Here, R is (CH 2 ) m -C (A) = C (B)- (CH 2 ) n Ar {wherein n and m represent an integer of 0 to 6, A and B may be the same or different, and represent a hydrogen atom, a halogen atom or an alkyl group, The configuration of the double bond is E or Z or an E + Z mixture, or A and B form a third bond between the carbon atoms to which they are attached and Ar is an optionally substituted aryl. Or represents a heterocyclic aryl group}, and Z Represents a hydrogen atom or the residue of a carboxylic acid containing up to 18 carbon atoms]. These have useful antibacterial activity. |