| abstract |
(57) [Summary] [Structure] A succinimide derivative represented by the following chemical formula 1 and salts thereof. [Chemical 1] (In the formula, R represents an amino group protected by a group capable of leaving by hydrogenolysis, a tert-butoxycarbonylamino group or a pyrrol-1-yl group, and R 1 represents a protective group for a carboxyl group. [Effect] The compound of the above chemical formula 1 is tetrahydropyrrolo [1,2] having a strong aldose reductase inhibitory action. -A] Pyrazine-4-spiro-3'-pyrrolidine derivatives, especially useful as intermediates in a process suitable for the industrial scale production of the more active enantiomers. |