| abstract |
(57) [Summary] (Corrected) The following general formula (I) Specifically, for example, (s) -3-((s) -2-te A ketone derivative represented by rt-butoxycarbonylamino-4-methylvalerylamino) -1-furfurylthio-2-heptanone or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as an active ingredient. [Effect] These ketone derivatives show strong inhibitory activity against thiol proteases such as papain, cathepsin B, cathepsin H, cathepsin L and calpain, and are also excellent in oral absorbability, tissue translocation and cell membrane permeability. Therefore, various uses are expected as pharmaceuticals. |