| abstract |
(57) [Summary] [Structure] General formula (1) (In the formula, R is naphthyl, 1,3-benzodioxolyl, An azepine derivative represented by a pyridyl or thienyl group and C * represents an asymmetric carbon atom) or a non-toxic salt thereof, a method for producing the same, and a therapeutic agent for a disease associated with a sigma receptor having the same as an active ingredient . [Effect] The compound (1) of the present invention and a non-toxic salt thereof have high affinity for sigma receptors and almost no affinity for other receptors, and diseases related to sigma receptors, such as schizophrenia. Can be advantageously used for the treatment of |