| abstract |
(57) [Summary] (Modified) [Objective] A compound effective as a 5-lipoxygease inhibitor is provided. [Structure] A pyrrolidine derivative represented by the following formula or a pharmaceutically acceptable salt thereof, a method for producing them, and a pharmaceutical composition containing the compound or a pharmaceutically acceptable salt thereof. [Wherein Ar 1 is phenyl, naphthyl, a 10-membered bicyclic heterocyclic group containing 1 to 2 heteroatoms (especially 1-methyl- 2-oxo-1,2-dihydroquinolin-6-yl group) Ar 2 is phenylene, pyridinediyl, thiophenediyl, etc .; A is a direct bond or C 1-4 alkylene; X is O or S (O) p (where p = 0, 1, 2) R 1 is C 1-4 alkyl and the like; R 2 is C 1-4 (halo) alkyl etc .; R 3 is H, OH, C 1-4 Alkyl, C 1-4 alkoxy; n is 1 or 2] |