| abstract |
(57) [Summary] (Modified) [Objective] To provide an acyl-coenzyme A: cholesterol acyltransferase inhibitor containing a pyrimidine base, a purine base and the like as active ingredients. [Structure] Acyl-coenzyme A: Cholesterol acyl transfer containing as active ingredient one or more selected from pyrimidine base, purine base, pyrimidine or nucleoside having purine base as a constituent or nucleotide having pyrimidine or purine base as a constituent Enzyme inhibitors. [Effect] Pyrimidine base, purine base, nucleoside having pyrimidine or purine base as a constituent or nucleotide having pyrimidine or purine base as a constituent has an inhibitory action on acyl-coenzyme A: cholesterol acyltransferase, and It is useful for prevention and treatment of various diseases related to sclerosis. |