| abstract |
(57) [Summary] (Modified) [Structure] A biphenyl derivative represented by the following general formula. (In the formula, one of R 1 and R 2 is a hydrogen atom, the other is a hydrogen atom, Amino group, mono-, di-lower alkylamino group, R 1 , R 2 is integrated into a carbonyl group, R 3 is a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, X is CH 2 or a group —N (R 4 ) — (where R 4 is a hydrogen atom, Lower alkyl group, lower alkanoyl group). [Effect] It has a vasopressin antagonism and is useful as a water diuretic, anti-heart failure agent, anti-hypertensive agent, etc. |