| abstract |
(57) [Summary] [Structure] General Formula (I) [Wherein R 1 and R 2 are hydrogen, halogen, alkyl, alkoxy, phenyl, etc., R 3 is hydrogen or a hydroxyl group, Ar is an aryl or heteroaryl which may have a substituent, X is oxygen, sulfur or N (R 6 ) (R 6 is hydrogen, alkyl or acyl), and A is a carbonyl group. an alkylene be, R 4, R 5 to form hydrogen, such as whether represents an alkyl, coupled to 1-pyrrolidinyl, piperidino, morpholino. ] The pyridine compound represented by these, or its acid addition salt. [Effect] The present compound has a highly selective inhibitory effect on synaptosome calcium influx, and is useful for the treatment of brain damage due to cerebral infarction, cerebral hemorrhage, traffic accident, and epilepsy. |