| abstract |
(57) [Summary] [Structure] A novel tryptophan derivative represented by the general formula (I). [Chemical 1] (In the formula, A is a single bond or a lower alkylene group, R 1 , R 2 means a hydrogen atom or an aralkyl group, R 3 means a methyl group or an ethyl group, and Trp means a tryptophan residue. However, a compound in which A is a single bond and R 3 is a methyl group is excluded. ) [Effect] Inhibits the activity of angiotensin converting enzyme, Preventing or treating hypertension etc. by lowering blood pressure. Further, it potently inhibits the activities of enkephalinase and dipeptidyl aminopeptidase, and thus is effective in treating pain. |