| abstract |
(57) [Summary] [Purpose] A novel substance capable of substantially neutralizing the above-mentioned human immunodeficiency virus (HIV) by binding to the glycoprotein antigen (gp120) having a molecular weight of about 120,000 daltons on the outer membrane. Various monoclonal antibodies or fragments thereof. [Structure] PND amino acid sequence 6 to 25 (NNTRKAIRVGP of PND of outer coat glycoprotein gp120 of isolated virus derived from HIV infected person) By using a synthetic peptide corresponding to GRTLYATRR) as an immunogen, a monoclonal antibody having neutralizing activity against a plurality of strains including the virus can be prepared. By transplanting the gene fragment encoding the variable region of the monoclonal antibody or the complementarity determining group of the region into the human antibody gene, a chimeric antibody or modified antibody having anti-HIV neutralizing activity can be obtained. |