| abstract |
(57) [Summary] (Modified) [Objective] An expression vector incorporating the human Id gene or a mutant thereof, a transformed cell into which the expression vector has been introduced, A diagnostic probe obtained by chemically synthesizing a partial sequence of a human Id gene base sequence or a mutant sequence thereof, and an antisense oligonucleotide comprising a partial sequence of a human Id gene base sequence or a base sequence complementary to the mutant sequence Offer. [Structure] Human Id gene (Id-1H and Id-1 H '), and variants thereof. Origin, production method, biochemical function, etc .: 3 types of mouse Id genes (Id-1, Id-2, Synthetic oligonucleotide 2 having a nucleotide sequence corresponding to a region having a common amino acid sequence encoded by HLH462) CD of human fibroblast TIG-1 using species as a probe A clone having a cDNA complementary to the probe is screened from the NA library by the hybridization method to isolate the human Id gene. |