| abstract |
(57) [Summary] (Modified) [Structure] A styrene derivative of the following formula or a salt thereof. [In the formula, R 1 and R 2 are a hydrogen atom, a lower alkoxy group, A halogen atom or a lower alkyl group, R 3 is a hydroxyl group, a lower alkoxy group, a lower alkyl group, a lower acyloxy group, an amino acid residue which may have a protecting group, and 1 is 0. Is an integer of 5 and m is an integer of 0 to 5. X is a general formula -N (Z) CO- [in the formula, Z is a general formula (CH 2 ) n A (in the formula, A is a hydrogen atom, a carboxyl group, a lower alkoxycarbonyl group, a cyano group, a lower alkoxy group, an N-acylamino group or the like or a substituent) A phenyl group, which may be In the pyridyl group or thienyl group, n represents an integer of 0 to 5)] or a single bond, and Y represents a divalent group such as -CZ '= CH- (in the formula, Z'is the same as Z). [Effect] It has excellent lipoxygenase inhibitory action and cyclooxygenase inhibitory action, and is useful as a therapeutic agent for anti-asthma agents, anti-allergic agents, anti-inflammatory analgesics, anti-rheumatic agents and the like. |