| abstract |
(57) [Summary] [Object] To provide a method for producing an optically active 1,2-diol derivative of the formula (I) of cis type. [Structure] In the presence of lipase, 1, of the cis type formula (I) Optical reaction of cis-formula (I) which can be used as an intermediate of optically active azole derivative of cis-formula (VII) by reacting 2-diol derivative with carboxylic acid derivative of formula (II) Active 1,2-diol derivatives can be prepared. In the formula, R 1 and R 2 each independently represent a hydrogen atom or an alkyl group, X represents a halogen atom, a nitro group, a cyano group, an alkyl group, a haloalkyl group, or a phenyl group, and n represents Indicates an integer of 0 to 5. R 3 is C 1 ~ C 10 alkyl group or an aryl group, R 4 represents a hydrogen atom, an alkyl group of C 1 ~ C 5, or alkenyl group of C 2 ~ C 4, a COR 3 group. The cis type indicates that the bond between the cyclopentane ring and the hydroxyl group and the bond between the cyclopentane ring and the benzyl group are in the same direction from the paper surface. [Chemical 1] [Chemical 2] [Chemical 3] |