| abstract |
(57) [Summary] [Object] The present invention provides a novel maleimide derivative useful as a water-soluble fluorescent labeling reagent for a compound having a thiol group, and a compound having a thiol group using the compound as a fluorescent labeling reagent. It is an object of the present invention to provide a fluorescent labeling method. [Effect] According to the present invention, antibodies, enzymes, Retaining these activities under mild conditions, the pyridylamino group, which was difficult to introduce into physiologically active substances such as hormones, various factors (eg growth factors, growth factors, etc.) and haptens while retaining these activities under mild conditions It has an excellent effect in that it can be introduced as it is, and it is a great invention that contributes to the related art. |