| abstract |
(57) [Summary] (Modified) [Constitution] An aminoquinolone derivative of the formula (Ia), a salt or ester thereof, and an AIDS therapeutic agent containing these compounds. [Wherein X is hydrogen, halogen; Y is hydrogen, halogen, lower alkyl, amino, etc .; Z is carboxy, etc .; Q is N or ═C (R 2 ) —; R is formula (h) or formula (i). R 1 is hydrogen, (substituted) alkyl, amino, cycloalkyl, phenyl, etc .; R 2 is (halo) lower alkoxy, lower alkyl, hydrogen, halogen, etc .; R 3 and R 6 are (substituted) aryl, (substituted) Heteroaromatic monocycle; R 4 , R 5 , and R 7 are hydrogen or lower alkyl; R 8 is hydrogen, lower alkyl, OH, or lower alkoxy; m = 0, 1; n = 1, 2; n ′ = 1, 2; n ″ = 1, 2, 3, 4. Effect The compound of formula (Ia) inhibits the proliferation of HIV in HIV-infected cells, and inhibits the cells induced by HIV. Suppresses denaturing effects. |