| abstract |
(57) [Summary] (Modified) [Structure] Chelate compound of general formula (I), method for producing the same, complex in which radioactive metal ion is coordinate-bonded to the chelate compound, and tumor containing the radioactive metal complex Therapeutic agent. [In the formula, R 1 is H, C 1-6 -alkyl group, and R 2 is C Each is a 1-6 -alkylene group, each of which may be substituted with 1 or 2 hydroxyl groups. R 3 and R 5 are H and C 1-6 - alkyl group; R 4 is H, (OH-substituted) C 1-6 - alkyl group; B is OH, NH 2, SH, phenyl or 3-pyridyl group substituted with like; the A (substituted) succinimide carbonyl - Fell group, an amino Fe enyl group, an isothiocyanate phenyl Represent. [Effect] This compound and its complex with a radioactive metal ion are used for the diagnosis and treatment of tumors. |