| abstract |
(57) [Summary] (Modified) [Objective] Inhibitors of oxygen 5-lipoxygenase and inhibitors of leukotriene biosynthesis. 【Constitution】 [Wherein Ar 1 is phenyl, naphthyl, in particular 1,2-be-dihydroquinoline-2-one ring, 10-membered heterocyclic ring containing; Ar 2 is phenylene, pyridylene, it is Pirishijiniren like; A 1 is a direct Represented or is C 1-3 -alkylene; X 1 is O, S, SO, SO 2 ; R 1 is H, C 1-4 -alkyl, etc .; R 2 is H, OH, C 1-4 Alkyl etc .; R 3 is halogen, CF 3 , C 1-4 -alkyl; p is 1 to 4; q is 0 to 2; r is 0 to 3; Tolerated salt, its manufacturing method, and a composition prepared by using the compound for leukotriene-mediated diseases or conditions. |