| abstract |
(57) [Summary] [Structure] The present invention mainly relates to the following formula I: [In the formula, X is O or NOH, Y is S or NR 3 , Ar is a group such as phenyl and naphthyl, and R is 1 to 4 substituents independently selected from hydrogen, hydroxy, lower alkyl and the like. And R 3 represents hydrogen or lower alkyl]. And a 4-aryl-thiazole or imidazole derivative represented by [Effect] The compound of the present invention increases the sensitivity of cardiac myofibrils to calcium, has phosphodiesterase inhibitory activity and bronchodilator activity, and is useful for the treatment of heart failure and asthma patients. |