http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0597699-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03d0f52bb4069f8a19d70dcfb697c67a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 1991-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71a6b3c6ca4ea28277596b168d5160cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51a36f5174187bbde975c5c836b0ff80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_927ef63f65bc55ed6453e09620c1c025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a08d70e2b1a9070424629f04dfc015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9f2b989286aeea588cc69941206aa9c |
| publicationDate | 1993-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0597699-A |
| titleOfInvention | Cancer metastasis inhibitor composed of polymer of propene amide derivative |
| abstract | (57) [Summary] [Structure] A cancer metastasis inhibitor comprising a polymer of a propenamide derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient. General formula (I) H 2 C = CR 1 -CO- [NH-R 2 -CO] - ([X] - Arg-Gly-Asp- [Y]) in n -Z formula, R 1 represents a hydrogen atom, Represents a methyl group or an ethyl group, R 2 Represents a linear or branched alkylene group having 1 to 11 carbon atoms, and the carbon atom in the alkylene group may be linked via -O-. X, Y are Ser, Gly, Val, T represents an amino acid residue selected from hr, Pro and Gln or a peptide residue composed of these amino acid residues, Z represents —OH, —OR 3 , —NR 4 R 5 and R 3, R 4 and R 5 are selected from hydrogen atom, methyl and ethyl groups. n represents an integer of 1 to 3. Also, in the formula [] Indicates that the residue in [] may or may not be present. [Effect] The propene amide derivative polymer of the present invention has greater cell adhesiveness than the core sequence of cell adhesive protein, has various biological activities such as cancer metastasis inhibitory action, and has almost no toxicity problem. In addition, its structure is simple and its synthesis is easy, and its value as a medicine is high. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105175623-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013123144-A1 |
| priorityDate | 1991-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 95.