| abstract |
(57) Summary [Structure] An atrial natriuretic factor analog containing an N-alkylated amino acid, which has the following amino acid sequence. [Chemical 13] (In the formula, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P and Q each represent one specific amino acid residue, and R represents 1 to 6 specific amino acid residues. Where at least one residue is an N-alkylated amino acid. [Effect] The above analog has natriuretic activity, diuretic activity, and vasorelaxant activity, and is effective for the treatment of congestive heart failure and renal vascular hypertension. |