| abstract |
(57) [Summary] (Modified) [Purpose] Suppress 5-lipoxygenase enzyme and / Alternatively, a compound useful for preventing and treating asthma, arthritis, psoriasis, ulcer, myocardial disease, thrombosis and related diseases in mammals by antagonizing PAF (platelet activating factor) is provided. [Structure] A compound having the following structural formula or a pharmaceutically acceptable acid addition salt thereof, or a pharmaceutically acceptable cation salt thereof when the above compound contains a carboxy group: [In the formula, R is 2- or 4-pyridyl, 2- or 4 - quinolyl, X is O, S or (CH 2) m, R 1 Is unsubstituted or substituted phenyl or pyridyl, n Is 0.1 or 2, m is 1 or 2, Y and Y 1 together form oxygen, Y is hydrogen, Y 1 is a hydroxy group, Z is CH 2 , NR 2 , 0 or S, R 2 represents hydrogen or alkyl] |