abstract |
(57) [Summary] [Object] To provide a 3-oxygermylpropionic acid readily soluble and disintegrating activated preparation and a cytopathic inhibitor containing the preparation as a main component. [Composition] A composition in which 3-oxygermylpropionic acid and a plurality of low-molecular substances, particularly sucrose, sorbitol, and fructose, are blended to prevent a decrease in the activity of 3-oxygermylpropionic acid due to high pressure processing, Provided is a compounded composition exhibiting a dose-dependent activity with little activity variation. This drug is easily and inexpensively manufactured by a high-pressure processing method, and is applied as an orally-administered tablet to a cytopathic inhibitor for liver damage. [Effect] The dissolution disintegration tablet that does not use a disintegrant eliminates the variation in release, activates the drug effect, and prevents the activity of 3-oxygermylpropionic acid from decreasing due to high-pressure processing, and can be combined with or used in combination with other agents. It will be possible. Further, the present invention provides an application as a preventive and protective agent against harmful substances having a cytopathic effect (radiation, radioactive substances, highly toxic compounds, etc.). |