| abstract |
(57) [Summary] (Modified) [Objective] To provide a method for producing an aryl (or heteroaryl) piperazinyl butyrazole derivative (I) having pharmacological activity on the central nervous system in good yield. [Structure] A method for producing a compound of the following general formula (I) by reacting a compound of the general formula (IX) with a compound of the general formula (III). [Wherein Ar is an optionally substituted N-containing or other aromatic group, Z 1 , Z 2 and Z 4 are N or C—R groups, and R and R 3 are H, halogen and a lower alkyl group. , Nitro group, Hydroxyl group, alkoxy group, cyano group, carboxyl group, carboxamide group, alkylcarboxylate group, aryl or substituted aryl group, sulfonyl group, sulfonamide group optionally substituted with amino group, or amino group or substituted amino group Indicates a group. ] |