| abstract |
(57) [Summary] (Modified) [Purpose] To find a novel substance having phospholipase A 2 inhibitory activity, which is useful as an anti-inflammatory agent. [Structure] General formula [Chemical formula 1] [In the formula, R 1 represents hydrogen, a halogen atom, an acyl group having 2 to 25 carbon atoms which may have a substituent, or an alkyl group which may have a substituent, and R 2 represents a hydrogen or an alkyl group. , An aralkyl group or an acyl group having 2 to 25 carbon atoms, and R 3 represents an optionally substituted hydroxyl group or a halogen atom. ] A method for producing a compound represented by the following, or a salt thereof, and a microorganism belonging to the genus Streptomyces and capable of producing the above-mentioned tetronic acid derivative are cultured, and the compound is collected from the culture. [Effect] The compound of the present invention has low toxicity and is an inflammatory disease, It can be expected to be used for treatment or prevention of allergic diseases, thrombotic diseases, arteriosclerosis and the like. |