| abstract |
(57) [Summary] [Structure] A novel tryptophan derivative represented by the general formula 1. [Chemical 1] (In the formula, A is a single bond or a lower alkylene group, R 1 , R 2 means a hydrogen atom or an aralkyl group, and Trp means a tryptophan residue. ) [Effects] The activity of angiotensin-converting enzyme and endothelin-converting enzyme is inhibited and blood pressure is lowered to prevent or treat hypertension and the like. Furthermore, it strongly inhibits enkephalinase activity and is effective in treating pain. |