| abstract |
(57) [Summary] (Modified) [Purpose] To provide a novel method for producing a phenoxyprostatrienoic acid derivative. [Structure] Formula (I) [R is lower alkyl (preferably methyl), X is hydrogen, Halo, trifluoromethyl, lower alkyl or lower alkoxy, wavy lines (two) represent α configuration or β configuration (where one wavy line is α configuration, the other wavy line is β configuration)] To produce a counterpart of natural origin prostaglandin configuration or a mixture thereof, a compound of formula (II) A compound (I) in which the acid group of the compound of [X and wavy line have the same meaning as above] or a corresponding substance having a non-naturally occurring prostaglandin configuration or a mixture thereof is esterified with a lower diazoalkane (preferably diazomethane) Alternatively, a method for producing the corresponding substance or a mixture thereof. |