| abstract |
(57) [Summary] [Purpose] A novel dopamine antagonist that acts on the dopamine D 3 receptor used as an antipsychotic drug, psychostimulant drug, anti-autism drug, anti-sedative drug, Parkinson's disease therapeutic drug or antihypertensive drug. Naphthamide derivatives as agents and methods for synthesizing them. [Structure] A novel naphthamide derivative of [Chemical formula 1]: (Where X is a hydrogen atom, chlorine atom, bromine atom, amino group, aminoalkyl group, aminosulfamoyl group, thiocyanate, alkylthio, sulfo group such as alkylsulfinyl or alkylsulfonyl group, methoxyl group, Or a nitro group, a cyano group, an electron-withdrawing group, Y represents an alkyl residue or an alkenyl residue, Z represents 2-aminomethyl-N-alkylpyrrolidine, 2-amino-ethyl-N, N-diethylamine, 2 -Aminoethylmorpholine, 2-aminoethyl-N, N-dibutylamine, 4 - amino -N- butyl piperidine, represents a residue derived from 2-aminoethyl pyrrolidine, R represents a hydrogen atom or a substituent OCH 3) |