| abstract |
(57) [Summary] (Modified) [Structure] A novel phenoxyacetic acid derivative represented by the general formula shown and a pharmaceutical preparation containing the same. (In the formula, X represents a hydrogen, halogen atom, lower alkyl, trifluoromethyl, alkoxy, hydroxy or cyano group, R 1 represents a hydrogen, methyl or ethyl group, A Represents a methyl, phenyl or 2-pyridyl group, R 2 represents hydrogen or a phenyl lower alkyloxy, pyridyl lower alkyloxy or naphthyl lower alkyloxy group, and n represents an integer of 0 to 2. [Effect] The novel phenoxyacetic acid derivative of the present invention has an excellent antagonistic effect on thromboxane A 2 (TXA 2 ), and is therefore effective as a TXA 2 antagonist. It is also effective as a drug for treating and preventing allergies and thrombosis, which are diseases caused by XA 2 . |