| abstract |
(57) [Abstract] [Purpose] Development of a novel protein, DNA and its transcribed mRNA for use in a simple diagnostic method for pancreatic diseases such as insulinoma or pancreatic cancer. [Structure] The whole nucleotide sequence of a new gene specifically expressed in rat insulinoma induced by streptozotocin-nicotinic acid amide or alloxan-nicotinic acid amide was determined and named as rig. Furthermore, in BK virus-induced hamster insulinoma and surgically excised human insulinoma, new genes that closely resemble the base sequence of rig were found, the entire amino acid sequences of the proteins encoded by these new genes were deduced, and new proteins were obtained. |