| abstract |
(57) [Summary] [Objective] To provide a gene encoding a rat proteasome component and a polypeptide of the component. [Structure] Amino acid sequences constituting the polypeptides of the components of rat proteasome, delta, iota, zeta, and RING12, and the nucleotide sequences of the genes encoding these polypeptides. Each of the above-mentioned components synthesizes cDNA from mRNA obtained from rat liver cells or the like, It is produced by growing an appropriate host cell transformed with the vector incorporating the double-stranded DNA synthesized from [Effect] Each of the above-mentioned components is useful for elucidating the mechanism of various malignant tumors and other pathological conditions, diagnosis and treatment. |