abstract |
(57) [Summary] [Purpose] To improve the stability of human growth hormone against degradation by enzymes without changing the biological activity of human growth hormone, compared with natural hGH. [Arrangement] The arginine residue at position 134 in the amino acid sequence of natural human growth hormone is replaced with an amino acid residue selected from the group consisting of L-alanine, L-leucine, L-threonine, L-phenylalanine, L-proline and L-histidine. Substitute with a group. |