| abstract |
(57) [Summary] (Modified) [Purpose] 3-Fluoro-3 with antiviral activity -Hydroxymethyl-2- (hydroxy or hydroxymethyl) cyclobutane and its intermediates, as well as methods for making the compounds are provided. A compound represented by the illustrated structural formula, a pharmaceutically acceptable salt thereof, and a cyclobutanal intermediate for synthesizing the compound. [Wherein R 1 is a (substituted) 9H-purin-9-yl group, a (substituted) 2,4-dioxotetrahydropyrimidin-1-yl group, a (substituted) 2-oxo-4-amino-dihydropyrimidin-1 be-yl group; R 6 is OH, CH 2 OH, - O-PO 3 H 2, -CH 2 -O-PO 3 H 2, -O-C O-R 3, be -CH 2 -O-CO-R 3 ; R 7 is H, -PO 3 H 2, be a -CO-R 3; R 3 is H, aryl, C 1 to 10 alkyl or the like R 4 is F, C 1, CF 3 , ethyl and the like. ] The compound shown by these, and its pharmaceutically acceptable salt. |