| abstract |
(57) [Summary] (Corrected) [Structure] [Wherein B 1 and B 2 are H, OH, etc., A is a bond, methylene, O, S, NR 4 or NCOR 5 , R 4 is H, alkyl, etc., R 5 is —CF 3 , alkyl, etc., R 1 is H, R 3 is H or —CH 2 OC (O) C (C H 3 ) 3 , n is an integer of 0 to 3, and Q is And the like]. As a concrete example, [4S- [4α, 7α (R * ), 12bβ]]-7- [(2-Mercaptomethyl-2-oxoindane) methylamino] -1,2,3,4,6,7,8,12b-octahydro-6-oxopyrido [2,1-a] [2] benzazepine-4- It is a carboxylic acid. [Effect] It is useful as an inhibitor of enkephalinase and ACE. |