abstract |
(57) [Summary] (Modified) [Purpose] Oxytocin and vasopressin antagonists that can be used for treatment of preterm labor and dysmenorrhea, termination of labor in preparation for Caesarean section, and congestive heart failure. Offer of. (1) A compound represented by the general formula shown and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing a pharmaceutically effective amount of the compound sufficient to competitively inhibit oxytocin. [Wherein R is Het-R ', Het is a 5- or 6-membered heterocyclic group, and may contain N, O, S in the ring, and R'is H, = O,-. NH 2 , (substituted) alkyl group, and the alkyl-substituted product is —OH, —NH 2 , ═O, —C OOH, -SO 2 - alkyl, phenyl, indole, Selected from imidazole, pyrrolidine, etc.] |