| abstract |
(57) [Summary] (Modified) [Structure] General formula AB [wherein A represents a cyclooxygenase inhibitor having a usable acid functional group, and the cyclooxygenase inhibitor is represented by the general formula RCOOH (where COOH is Represents a possible acid functional group, and R represents a suitable residue of the cyclooxygenase inhibitor). B is the following formula: (In the formula, R 1 represents a hydrogen atom, a methyl group or an ethyl group, R 2 represents a hydrogen atom or a nitro group, R 3 represents an amino group, a methylamino group, an ethylamino group, a hydrazino group, a methyl group or an ethyl group. Represents a group; provided that when AB is a salt and R 2 represents a hydrogen atom, R 3 represents an L form of an arginine analog represented by the formula). A compound, which may be a salt or an amide, a process for producing the same, and a pharmaceutical composition containing the compound. [Effect] The above compound has L-arginine / nitric oxide inhibitory action and cyclooxygenase inhibitory action, and is useful for treating heart and cerebrovascular disorders, inflammation, immunodeficiency and the like. |