| abstract |
(57) Summary: The present invention recognizes and / or recognizes the HIV core protein p24 expressed on the surface of HIV-infected macrophages. Alternatively, the present invention relates to a monoclonal antibody against HIV core protein p24 that kills HIV-infected macrophages and derivatives thereof. The antibody can be a mouse antibody or a chimeric antibody consisting of a human constant region and a mouse variable region or hypervariable region. The present invention provides a method for producing the antibody, a hybridoma or transfectoma cell line secreting them, a recombinant DNA comprising an insert fragment encoding the variable region of an antibody against the HIV core protein p24 having the above-mentioned properties, A method for producing recombinant DNA, And a host cell transformed with the recombinant DNA. [Effect] The antibody of the present invention prevents the progression of AIDS and AIDS. It can be used to treat HIV and further to diagnose HIV infection in immunoassays. |