| abstract |
(57) [Summary] [Object] The present invention provides a novel human TNF transformant having an antitumor effect similar to that of human TNF or a transformant thereof, while not exhibiting the cancer metastasis-enhancing effect recognized by them. provide. [Structure] The first Ser shown in SEQ ID NO: 1 in the sequence listing To the 155th Leu to the tumor necrosis factor polypeptide having the amino acid sequence or its transformant, the 1st Ser to the 8th Asp of SEQ ID NO: 1 Up to or including the amino acid sequence of the corresponding transformant containing at least one amino acid sequence of Arg-Gly-Asp, and being substituted with an amino acid sequence containing 3 to 16 amino acids , It relates to the converted polypeptide, plasmid, transformant, production method, pharmaceutical composition, or DNA. |