| abstract |
(57) [Summary] (Corrected) [Constitution] The following formula: (I) [Wherein R 1 and R 2 are (substituted) aryl, heteroaryl, etc., A is a nitrogen atom or a CH group, and E is a group — (C H 2 ) P −, —O— (CH 2 ) P −, etc. 3 or 4, Q is a nitrogen atom or a CH group, R 3 is a hydrogen atom or an alkyl group, X is an oxygen atom, a sulfur atom, etc., and m is 2 to 8, n is an integer of 1 to 4, Y represents a sulfur atom, an oxygen atom or a methylene group], and a method for producing the same. [Effect] The above arylalkylamine derivatives can be used for the prevention and treatment of histamine-related diseases because of their antagonism of histamine H 1- and H 2 receptors. |