| abstract |
(57) [Summary] [Structure] The culture step or the purification step is performed in the presence of an amine compound selected from alkylamines, diamines, guanidines, benzamidines, basic amino acids, and aminophenylacetic acid. A method for suppressing coloration of human serum albumin that is expressed by a characteristic genetic manipulation. [Effect] According to the method of the present invention, the degree of coloring of HSA expressed by genetic engineering is 1/2 to that of untreated HSA. It can be suppressed to about 1/10. In addition, the recovery rate of HSA is good, and the original properties of HSA do not change at all. |